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Merck

44577

Sigma-Aldrich

Doxycycline hyclate

≥98.0% (TLC)

Synonim(y):

Doxycycline hydrochloride hemiethanolate hemihydrate

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About This Item

Wzór empiryczny (zapis Hilla):
C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O
Numer CAS:
Masa cząsteczkowa:
512.94
Beilstein:
5702728
Numer MDL:
Kod UNSPSC:
51101500
Identyfikator substancji w PubChem:

pochodzenie biologiczne

synthetic

Próba

≥98.0% (TLC)

Formularz

powder

zanieczyszczenia

≤5% water
≤7% ethanol

kolor

faintly yellow to yellow

rozpuszczalność

H2O: 50 mg/mL, clear, yellow-green

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites

Tryb działania

protein synthesis | interferes

ciąg SMILES

Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58

InChI

1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1

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Opis ogólny

Chemical structure: tetracycline

Działania biochem./fizjol.

Mode of Action: Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi.

Activity Spectrum: Effective against a broad spectrum inhibitor of matrix metalloproteinases in vivo.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
This product has been replaced by D9891-SIGMA | Doxycycline hyclate ≥98% (TLC)

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Certyfikaty analizy (CoA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

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    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is doxycycline hyclate soluble in DMSO?

    According to literature sources, doxycycline hyclate is soluble in DMSO at a concentration of 100 mM.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Hanumara Ram Chowdri et al.
Annals of internal medicine, 159(1), 21-27 (2013-07-03)
The diverse tickborne infections of the northeastern United States can present as undifferentiated flu-like illnesses. In areas endemic for Lyme and other tickborne diseases, patients presenting with acute febrile illness with myalgia, headache, neutropenia, thrombocytopenia, and elevated hepatic aminotransferase levels
Alicia Anderson et al.
MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 62(RR-03), 1-30 (2013-03-29)
Q fever, a zoonotic disease caused by the bacterium Coxiella burnetii, can cause acute or chronic illness in humans. Transmission occurs primarily through inhalation of aerosols from contaminated soil or animal waste. No licensed vaccine is available in the United
Xuefeng Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13870-13875 (2014-09-06)
Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of the primary tumor. Here we show that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensable for
C Arnoud Meijer et al.
Annals of internal medicine, 159(12), 815-823 (2014-02-04)
Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans. To test whether doxycycline inhibits AAA progression in humans. Randomized, placebo-controlled, double-blind
Steve Ramirez et al.
Science (New York, N.Y.), 341(6144), 387-391 (2013-07-28)
Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were

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