401757

Tetrahydrofuran

≥99.9%, anhydrous, inhibitor-free

• Synonim(y): THF, Butylene oxide, Oxolane, Tetramethylene oxide
• Wzór liniowy: (CH₂)₃CH₂O
• Numer CAS: 109-99-9
• Masa cząsteczkowa: 72.11
• NACRES: NA.21
• PubChem Substance ID: 57649919
• UNSPSC Code: 12191501
• EC Number: 203-726-8
• MDL number: MFCD00005356
• Beilstein/REAXYS Number: 102391
• Assay: ≥99.9%
• Grade: anhydrous
• Bp: 65-67 °C (lit.)
• Vapor pressure: 114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

Właściwości

• Nazwa produktu: Tetrahydrofuran, anhydrous, ≥99.9%, inhibitor-free
• grade: anhydrous
• Quality Segment: 200
• vapor density: 2.5 (vs air)
• vapor pressure: 114 mmHg ( 15 °C), 143 mmHg ( 20 °C)
• assay: ≥99.9%
• form: liquid
• autoignition temp.: 610 °F
• expl. lim.: 1.8-11.8 %
• impurities: ≤20 ppm peroxide (as H₂O₂), <0.002% water, <0.005% water (100 mL pkg)
• evapn. residue: <0.0005%
• refractive index: n20/D 1.407 (lit.)
• pH: ~7
• bp: 65-67 °C (lit.)
• mp: −108 °C (lit.)
• solubility: H₂O: soluble
• density: 0.889 g/mL at 25 °C (lit.)
• SMILES string: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• InChI key: WYURNTSHIVDZCO-UHFFFAOYSA-N

Opis

General description

Our anhydrous solvents deliver exceptionally low water content, making them the ideal choice for moisture-sensitive laboratory applications. Packaged in the exclusive Sure/Seal^™ septum bottle system, they are reliably protected against moisture ingress from first use to last drop. The innovative Sure/Seal^™ closure combines an advanced plug-style liner with an airtight elastomer and crimp cap design to ensure consistent product integrity. Three unique liner materials provide optimal chemical compatibility across a broad range of solvents. Sure/Seal^™ packaging is proven to maintain anhydrous conditions even after repeated punctures. With more than 70 products across all major solvent families, available in pack sizes from 100 mL to 2 L, the portfolio meets virtually every laboratory need. By choosing ready-to-use anhydrous solvents in Sure/Seal^™ packaging, researchers eliminate the need for time-consuming and hazardous in-house solvent drying and distillation - saving time, reducing risk, and improving reproducibility.

Application

Anhydrous solvents in Sure/Seal^™ packaging are essential wherever water contamination would compromise experimental results. They are widely used in moisture-sensitive applications such as organic synthesis - including Grignard reactions, organometallic chemistry, and catalysis - as well as in peptide, oligonucleotide, and pharmaceutical synthesis.

Packaging

View returnable container options.

Other Notes

"Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (673277) and Cyclopentyl methyl ether (791962)

Read more about THF alternatives:

2-Methyltetrahydroun (2-MeTHF): A biomass-Derived solvent with Broad Applications in Organic Chemistry

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent"

Pure-Pac^® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• pictograms: GHS02,GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H302,H318,H335,H336,H351
• target_organs: Central nervous system, Respiratory system
• supp_hazards: EUH019
• Klasa składowania: 3 - Flammable liquids
• flash_point_f: -6.2 °F - closed cup
• flash_point_c: -21.2 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
• pcodes: P202 - P210 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3