17929

O-Methyl-O′-succinylpolyethylene glycol 5′000

• Synonim(y): Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate
• Wzór liniowy: CH₃O(CH₂CH₂O)_nCOCH₂CH₂COOH
• Numer CAS: 31961-02-1
• UNSPSC Code: 51171641
• NACRES: NA.26
• MDL number: MFCD00284260

Właściwości

• form: powder
• Quality Segment: 100, 200
• mol wt: M_r ~5100
• mp: 56-60 °C
• Ω-end: carboxylic acid
• α-end: methoxy
• storage temp.: −20°C

Opis

Application

Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG

Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Biochem/physiol Actions

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves