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Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 5′000

Synonim(y):

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate

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About This Item

Wzór liniowy:
CH3O(CH2CH2O)nCOCH2CH2COOH
Numer CAS:
31961-02-1
Numer MDL:
MFCD00284260
Kod UNSPSC:
51171641
NACRES:
NA.26

Postać

powder

masa cząsteczkowa

Mr ~5100

mp

56-60 °C

Ω-koniec

carboxylic acid

α-koniec

methoxy

temp. przechowywania

−20°C

Zastosowanie

Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.
Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG

Działania biochem./fizjol.

O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number
063737/2
063737/2
2106A
63737/2
63737/1

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Methoxypolyethylene glycol 350 average mol wt 350

Sigma-Aldrich

M6768

Methoxypolyethylene glycol 350

Poly(ethylene glycol) methyl ether average Mn 550

Sigma-Aldrich

202487

Poly(ethylene glycol) methyl ether

Enhanced stability of PEG-block-poly(N-hexyl stearate l-aspartamide) micelles in the presence of serum proteins.
Diezi TA, Bae Y, Kwon GS.
Molecular Pharmacology, 7, 1355-1360 (2010)
Telli Hekmatara et al.
Journal of nanoscience and nanotechnology, 9(8), 5091-5098 (2009-11-26)
Hydrophobic drugs, loperamide and paclitaxel, were loaded in poly(butyl cyanoacrylate) nanoparticles by polymerization of n-butyl-2-cyanoacrylate in aqueous-organic media in the presence of a drug. The particles were stabilized by dextran 70,000 and poloxamer 188 or by 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] sodium salt.
Mario Beyer et al.
Methods in molecular biology (Clifton, N.J.), 570, 309-316 (2009-08-04)
Combinatorial synthesis of peptides on solid supports (1), either as spots on cellulose membranes (2) or with split-pool-libraries on polymer beads (3), substantially forwarded research in the field of peptide-protein interactions. Admittedly, these concepts have specific limitations, on one hand
A Bogdanov et al.
Journal of drug targeting, 4(5), 321-330 (1997-01-01)
A co-polymer of O-methyl polyethylene(glycol)-O'-succinate (MPEGs, m.w. 5100) and poly-l-lysine (PL, median m.w. 32700, degree of polymerization 256) has been synthesized by covalent grafting. The resultant MPEGs-PL (30% modification degree of epsilon-amino groups) had a hydrodynamic diameter corresponding to a
M. Joppich, P.L. Luisi
Makromol. Chem., 180, 1381-1381 (1979)
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