14385

Biochanin A

≥97.0% (TLC)

• Synonim(y): 4′-Methylgenistein, 5,7-Dihydroxy-4′-methoxyisoflavone, Genistein 4′-methyl ether, Olmelin
• Wzór empiryczny (zapis Hilla): C₁₆H₁₂O₅
• Numer CAS: 491-80-5
• Masa cząsteczkowa: 284.26
• EC Number: 207-744-7
• UNSPSC Code: 12352200
• MDL number: MFCD00006839
• Beilstein/REAXYS Number: 278107

Właściwości

• assay: ≥97.0% (TLC)
• mp: 210-213 °C (lit.), 212-218 °C
• solubility: acetone: 10 mg/mL, clear, brown
• SMILES string: COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3
• InChI key: WUADCCWRTIWANL-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels.

Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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