SCT065
Green-AlDeSense ALDH1A1 Live Cell Dye
ALDH1A1 isoform specific live cell dye which labels cancer stem cells for fluorescent microscopy, flow cytometry and in vivo applications.
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About This Item
Kod UNSPSC:
12352207
NACRES:
NA.47
Polecane produkty
metoda wykrywania
fluorometric
Opis ogólny
Cancer stem cells (CSCs) have an increased capacity to activate antiapoptotic/prosurvival pathways as well as overexpressing ATP-binding cassette transporters which act as potent efflux pumps for potential chemotherapeutics. Aldehyde dehydrogenases (ALDH), in particular the ALDH1A1 isoform, is believed to be a reliable marker of CSCs across many cancer types, including prostate, lung, breast, esophageal, and ovarian cancers. ALDH1A1 is associated with increased chemotherapy resistance and poor clinical outcome and is an established stem cell marker.
Current methods to identify ALDH in living cells are limited by cross-reactivity with several ALDH isoforms producing difficulties in data analysis and prognosis. Chan, et al. have created a ALDH1A1 isoform specific live cell dye termed Green-AlDeSense which labels cancer stem cells and exhibits a 20-fold fluorescent enhancement when bound to ALDH1A1. The dye identifies ALDH1A1 positive CSCs using live cell imaging, flow cytometry and in vivo studies.
Spectral Properties: absmax: 496 nm, emmax: 516 nm.
Current methods to identify ALDH in living cells are limited by cross-reactivity with several ALDH isoforms producing difficulties in data analysis and prognosis. Chan, et al. have created a ALDH1A1 isoform specific live cell dye termed Green-AlDeSense which labels cancer stem cells and exhibits a 20-fold fluorescent enhancement when bound to ALDH1A1. The dye identifies ALDH1A1 positive CSCs using live cell imaging, flow cytometry and in vivo studies.
Spectral Properties: absmax: 496 nm, emmax: 516 nm.
Przechowywanie i stabilność
Store at -20C. Protect from light.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
11 - Combustible Solids
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