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Merck

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AB1555

Anti-NMDAR2A Antibody

serum, Chemicon®

Synonim(y):

Anti-EPND, Anti-GluN2A, Anti-LKS, Anti-NMDAR2A, Anti-NR2A

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Gabaryty przesyłkiSKUDostępnośćCena netto
50 μL

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

2060,00 zł

Informacje o tej pozycji

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
44

2060,00 zł


Dostępne do wysyłki DZISIAJSzczegóły

Rekombinowane, niezawierające konserwantów przeciwciało jest dostępne dla Twojego celu. Wypróbuj ZRB04901

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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

fish, human, rat, mouse

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

suitability

not suitable for immunohistochemistry

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Ta pozycja
AB5403SAB5200888SAB5200994
biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

mouse

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

phycoerythrin (R-PE) conjugate

antibody form

serum

antibody form

affinity purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

species reactivity

fish, human, rat, mouse

species reactivity

rat

species reactivity

mouse, human, rat

species reactivity

human, rat, mouse

Immunogen

C-Terminal Fusion Protein of the NMDAR2A (30 kDa), aa 1253-1391.

Application

Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
This Anti-NMDAR2A Antibody is validated for use in IP, WB for the detection of NMDAR2A.
Western blotting*: 1:1,000-1:5,000 for ECL. If using labled protein-A for detection: 1:200.

* See suggested protocol

Immunoprecipitation using solubilized hippocampal slices. 3μL will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200μg rat brain.

Not suggested for use in immunohistochemistry.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

NMDAR2A. By Western blot it recognizes a 180 kDa band in rat brain membranes.

Physical form

Rabbit antiserum. Liquid, no preservatives.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
NMDAR2A is present in high concentrations in the hippocampus

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Klasa składowania

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Zhen-Zhen Duan et al.
Scientific reports, 6, 29246-29246 (2016-07-08)
It has been demonstrated that Src could modulate NMDA receptor, and PAR1 could also affect NMDAR signaling. However, whether PAR1 could regulate NMDAR through Src under ICH has not yet been investigated. In this study, we demonstrated the role of
Effects of repeated prenatal glucocorticoid exposure on long-term potentiation in the juvenile guinea-pig hippocampus.
Setiawan, E; Jackson, MF; MacDonald, JF; Matthews, SG
The Journal of Physiology null
Visual experience-independent functional expression of NMDA receptors in the developing rabbit retina.
Chang, YC; Chen, CY; Chiao, CC
Investigative Ophthalmology & Visual Science null
Annabelle Schlüter et al.
Molecular therapy. Methods & clinical development, 17, 281-299 (2020-02-15)
In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which neural damage
Sharon A Swanger et al.
American journal of human genetics, 99(6), 1261-1280 (2016-11-15)
Epilepsy and intellectual disability are associated with rare variants in the GluN2A and GluN2B (encoded by GRIN2A and GRIN2B) subunits of the N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel with essential roles in brain development and function. By assessing genetic

Powiązane treści

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

Numer pozycji handlu globalnego

SKUNUMER GTIN
AB155504053252363801

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