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8.00907

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

Synonim(y):

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

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Do Państwa/SKUDostępnośćCena netto
500 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
151,00 zł
1 g
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
257,00 zł
5 g
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
551,00 zł
25 g
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1500,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C8H17N3 · xHCl
Numer CAS:
25952-53-8
Masa cząsteczkowa:
155.24 (free base basis)
UNSPSC Code:
12352107
EC Index Number:
247-361-2
NACRES:
NA.22
MDL number:
MFCD00012503

151,00 zł

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Nazwa produktu

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis

Quality Segment

200

form

solid

reaction suitability

reaction type: Coupling Reactions

mp

110-115 °C

application(s)

peptide synthesis

storage temp.

−20°C (−15°C to −25°C)

SMILES string

Cl.N(CCCN(CC)C#N)(C)C

InChI

1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H

InChI key

FDXPUDRRFDHONO-UHFFFAOYSA-N

General description

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

Application

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:
  • A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
  • A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
  • A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.
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signalword

Danger

flash_point_f

Not applicable

flash_point_c

Not applicable

target_organs

Stomach,large intestine,lymph node

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Klasa składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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Certyfikaty analizy (CoA)

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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. The packaging instructions recommend storing the item under an inert gas, but the safety data sheet does not specify this requirement. Would it suffice to store it in a refrigerator at -20°C instead?

    1 answer

    1. The recommended long term storage of this item is -15°C to -25°C. Clearing the headspace of the vial with argon before resealing is recommended. The stability of the product when stored otherwise cannot be guaranteed.

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