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Merck

676380

Valproic Acid sodium salt

≥98% (HPLC), solid, HDAC1 inhibitor, Calbiochem®

Synonim(y):

Valproic Acid, Sodium Salt, 2-Propylpentanoic Acid, Na

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5 G

354,00 zł

354,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C8H15NaO2
Numer CAS:
1069-66-5
Masa cząsteczkowa:
166.19
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
MFCD00078604
eCl@ss:
42020819
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)

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Nazwa produktu

Valproic Acid, Sodium Salt, A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1).

Quality Level

100

description

Merck USA index - 14, 9913

assay

≥98% (HPLC)

form

solid

potency

400 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].[O-]C(=O)C(CCC)CCC

InChI

1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

InChI key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

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Ta pozycja
P4543524403459620
Valproic Acid, Sodium Salt A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1).

Sigma-Aldrich

676380

Valproic Acid, Sodium Salt

Valproic acid sodium salt 98%

P4543

Valproic acid sodium salt

Pravastatin, Sodium Salt A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM).

Sigma-Aldrich

524403

Pravastatin, Sodium Salt

Okadaic Acid, Sodium Salt Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.

Sigma-Aldrich

459620

Okadaic Acid, Sodium Salt

assay

≥98% (HPLC)

assay

98%

assay

≥98% (HPLC)

assay

≥98% (TLC)

form

solid

form

powder

form

crystalline solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

−20°C

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, protect from light

General description

A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50 = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
HDAC1
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Other Notes

Gottlicher, M., et al. 2001. EMBO J.20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res.21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674.
Chen, G., et al. 1999. J. Neurochem.72, 1327.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certyfikaty analizy (CoA)

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676380-5GM04055977183566

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