613560

TMPyP4

≥90% (TLC), solid, telomerase inhibitor, Calbiochem^®

• Synonim(y): TMPyP4, meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate
• Wzór empiryczny (zapis Hilla): C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
• Numer CAS: 36951-72-1
• Masa cząsteczkowa: 1363.60
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00013468
• Assay: ≥90% (TLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Właściwości

• Nazwa produktu: TMPyP4, A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).
• Quality Segment: 100
• assay: ≥90% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: purple
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3
• InChI key: AKZFRMNXBLFDNN-UHFFFAOYSA-K

Opis

General description

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 6.5 µM inhibiting human telomerase

Other Notes

Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable