612080

TIMP-1

≥90% (SDS-PAGE), liquid, MMP inhibitor, Calbiochem^®

• Synonim(y): Tissue Inhibitor of Metalloproteinase-1
• UNSPSC Code: 12352202
• NACRES: NA.77
• Assay: ≥90% (SDS-PAGE)
• Form: liquid
• Storage condition: OK to freeze, avoid repeated freeze/thaw cycles

Właściwości

• Nazwa produktu: TIMP-1, Human Neutrophil Granulocyte, Native TIMP-1 from human granulocyte.
• Quality Segment: 100
• assay: ≥90% (SDS-PAGE)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, avoid repeated freeze/thaw cycles
• shipped in: wet ice
• storage temp.: −70°C

Opis

General description

Native TIMP-1 from human granulocyte. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stoichiometric complex with latent and active MMPs. Binds to pro-MMP-9 and MMP-9 via their C-terminal domains.

Biochem/physiol Actions

Cell permeable: no

Primary Target
MMP activity

Product does not compete with ATP.

Reversible: no

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 200 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% Brij^® 35 Detergent, 0.05% NaN₃, pH 7.0.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Prepared from stimulated neutrophils that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Kolkenbrock, H., et al. 1996. Biol. Chem. 377, 529.
Kolkenbrock, H., et al. 1995. Biol. Chem. Hoppe Seyler 376, 495.

Legal Information

Brij is a registered trademark of Croda International PLC

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable