585970

(±)-Thalidomide

Selective inhibitor of TNF-α biosynthesis.

• Synonim(y): (±)-Thalidomide, (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Wzór empiryczny (zapis Hilla): C₁₃H₁₀N₂O₄
• Numer CAS: 50-35-1
• Masa cząsteczkowa: 258.23
• UNSPSC Code: 12352200
• MDL number: MFCD00153873
• eCl@ss: 39180303
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 25 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
• InChI key: UEJJHQNACJXSKW-UHFFFAOYSA-N

Opis

General description

Selective inhibitor of TNFα biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.

Selective inhibitor of TNF-α biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.

Biochem/physiol Actions

Cell permeable: no

Primary Target
TNF-α biosynthesis

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Gershon, D. 1995. Nat. Med.1, 1230.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301,H312,H360D
• Ostrzeżenia: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3