481406

NF-κB Activation Inhibitor

≥98% (HPLC), solid

• Synonim(y): NF-κB Activation Inhibitor, 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
• Wzór empiryczny (zapis Hilla): C₂₂H₂₀N₄O
• Numer CAS: 545380-34-5
• Masa cząsteczkowa: 356.42
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD06411436
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Nazwa produktu: NF-κB Activation Inhibitor, The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: N(CCc3ccc(cc3)Oc4ccccc4)c1ncnc2c1cc(cc2)N
• InChI: 1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
• InChI key: IBAKVEUZKHOWNG-UHFFFAOYSA-N

Opis

General description

A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC₅₀ = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC₅₀ = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.

Biochem/physiol Actions

Product does not compete with ATP.

Cell permeable: yes

Primary Target
NF-κB transcriptional activation

Reversible: no

Target IC₅₀: 11 nM against NF-κB transcriptional activation in Jurkat cells

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tobe, M., et al. 2003. Bioorg. Med. Chem.11, 383.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3