480025
NEMO-Binding Domain Binding Peptide, Cell-Permeable
A cell-permeable Antennapedia-NBD (wild type) fusion peptide that exhibits anti-inflammatory properties.
Synonim(y):
NEMO-Binding Domain Binding Peptide, Cell-Permeable, DRQIKIWFQNRRMKWKKTALDWSWLQTE, NBD-Binding Peptide, Cell Permeable
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About This Item
Wzór empiryczny (zapis Hilla):
C170H259N49O42S
Masa cząsteczkowa:
3693.24
Kod UNSPSC:
41116107
Informacje o cenach i dostępności nie są obecnie dostępne.
Polecane produkty
Poziom jakości
Próba
≥95% (HPLC)
Formularz
lyophilized solid
producent / nazwa handlowa
Calbiochem®
warunki przechowywania
OK to freeze
desiccated (hygroscopic)
kolor
white
rozpuszczalność
DMSO: 50 mg/mL
Warunki transportu
ambient
temp. przechowywania
−20°C
Opis ogólny
A cell-permeable Antennapedia-NBD (NEMO binding domain) (wild type) fusion peptide that exhibits anti-inflammatory activity in mouse model of acute inflammation. NBD is an amino terminal α-helical region of the NEMO (NF-κB essential modifier; IKKγ) associated with a carboxyl-terminal segment of IKKα and IKKβ. This peptide blocks the association of NEMO with the IKK complex and prevents NF-κB activation. NEMO is also reported to suppress the intrinsic basal activity of the IKK complex. Its anti-inflammatory properties are attributed to the inhibition of cytokine-induced NF-κB activation and NF-κB-dependent gene expression. Does neither affect the TNF-α-induced phosphorylation of c-Jun nor the DNA binding of Oct-1 transcription factor.
A cell-permeable Antennapedia-NBD (wild type) fusion peptide that exhibits anti-inflammatory properties. Acts by inhibiting cytokine-induced NF-κB activation and NF-κB-dependent gene expression. Suggested to block the interaction of NEMO with the IKK (IκB)-kinase complex and thereby prevents NF-κB activation. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
Działania biochem./fizjol.
Cell permeable: yes
Primary Target
cytokine-induced NF-κB activation and NF-κB-dependent gene expression
cytokine-induced NF-κB activation and NF-κB-dependent gene expression
Product does not compete with ATP.
Reversible: no
Opakowanie
Packaged under inert gas
Ostrzeżenie
Toxicity: Standard Handling (A)
Sekwencja
H-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu-OH
Postać fizyczna
Supplied as a trifluoroacetate salt.
Rekonstytucja
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Inne uwagi
Jimi, E., et al. 2004. Nat. Med., 10, 617.
Siegmund, D., et al. 2001. J. Biol. Chem.276, 43708.
May, M.J., et al. 2000. Science289, 1550.
Li, Q., et al. 1999. Science284, 321.
Siegmund, D., et al. 2001. J. Biol. Chem.276, 43708.
May, M.J., et al. 2000. Science289, 1550.
Li, Q., et al. 1999. Science284, 321.
Note: This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations. However, sufficient material will stay in the medium to permeate cells.
Informacje prawne
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Sang Jun Han et al.
JCI insight, 5(19) (2020-09-18)
We determined that renal proximal tubular (PT) NF-κB essential modulator (NEMO) plays a direct and critical role in ischemic acute kidney injury (AKI) using mice lacking renal PT NEMO and by targeted renal PT NEMO inhibition with mesoscale nanoparticle-encapsulated NEMO
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
Alessia Oppezzo et al.
The Journal of clinical investigation, 130(3), 1377-1391 (2019-12-27)
Hematopoietic stem cell (HSC) attrition is considered the key event underlying progressive BM failure (BMF) in Fanconi anemia (FA), the most frequent inherited BMF disorder in humans. However, despite major advances, how the cellular, biochemical, and molecular alterations reported in
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