444294-M

MMP-2 Inhibitor IV

The MMP-2 Inhibitor IV controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonim(y): MMP-2 Inhibitor IV, (4′-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid, Bone Resorption Inhibitor, Bone Resorption Inhibitor, (4′-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
• Wzór empiryczny (zapis Hilla): C₁₃H₁₄ClNO₈P₂S
• Masa cząsteczkowa: 441.72
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥99% (HPLC)
• Form: powder
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥99% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 100 mg/mL, clear, colorless
• storage temp.: 2-8°C

Opis

General description

A cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC₅₀ = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (>1 M), and MMP-14 (>1 M). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC₅₀ = 1.7 M), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC₅₀ = 30 M), and Zolendronate (7.8 M), without observable cytotoxicity in HepG2 cells. At 25 M, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Rubino, M.T., et al. 2011. Chem. Med. Chem.6, 1258.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable