344037
cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem
The cFMS Receptor Inhibitor II, also referenced under CAS 959860-85-6, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonim(y):
cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem, 4-(3,4-Dimethylanilino)-7-(4-pyridyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor II
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C23H20N4O
Numer CAS:
Masa cząsteczkowa:
368.43
UNSPSC Code:
12352200
Pomoc techniczna
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Pozwól nam pomócQuality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 80 nM). Although equally potent as cFMS Receptor Inhibitor III (Cat. No. 344038) in inhibiting the cFMS-dependent growth of M-NSF-60 cells (IC50 = 0.1 µM), this inhibitor is much more selective against cFMS-independent growth of NSO cells (IC50 >50 µM).
A cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 80 nM). Although equally potent as cFMS Receptor Inhibitor III (Cat. No. 344038) in inhibiting the cFMS-dependent growth of M-NSF-60 cells (IC50 = 0.1 µM), this inhibitor is much more selective against cFMS-independent growth of NSO cells (IC50 >50 µM).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Smalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett.17, 6257.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Klasa składowania
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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