341600

Fibrinogen, Fragment D, Human Plasma

Fibrinogen fragment D is a thermolabile native human plasma protein prepared by digestion of purified fibrinogen followed by preparative electrophoresis.

• NACRES: NA.41
• UNSPSC Code: 12352202
• Form: lyophilized

Właściwości

• Quality Segment: 200
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• impurities: ≤1% Fragment E
• solubility: sterile distilled water: 200 μg/mL
• shipped in: ambient
• storage temp.: −20°C

Opis

General description

Native fibrinogen fragment D from human plasma prepared by plasmin digestion of purified fibrinogen followed by preparative electrophoresis. Thermolabile fragment. Complete proteolysis of a single fibrinogen molecule produces two D and one E fragments. Fragment D has been shown to increase endothelial monolayer permeability and to decrease polymorphonuclear leukocyte adhesion to endothelial cells. The D and E fragments have no common antigenic determinants; therefore, no cross-reactivity occurs.

Physical form

Lyophilized from 400 mM glycine, 150 mM NaCl.

Preparation Note

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 4 h at 20°C or for up to 8 h at 4°C or for up to 3 months at -70°C.

Analysis Note

single band by SDS-PAGE

Other Notes

Spraggon, G., et al. 1997. Nature 389, 455.
Stirk, C.M., et al. 1993. Atherosclerosis103, 159.
Vogel, P., et al. 1993. Eur. Surg. Res.25, 83.
Azpiazu, I., and Chapman, D. 1992. Biochim. Biophys. Acta1119, 268.
Thompson, W.D., et al. 1992. J. Pathol.168, 47.
Fisher, E.G., et al. 1991. Haemostasis21, 141.
Ge, M., et al. 1991. Am. J. Physiol.261, L283.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable