341215

Exotoxin A, Pseudomonas aeruginosa - CAS 91262-95-2 - Calbiochem

Shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2.

• Synonim(y): Exotoxin A, Pseudomonas aeruginosa - CAS 91262-95-2 - Calbiochem
• Numer CAS: 91262-95-2
• UNSPSC Code: 12352200
• MDL number: MFCD00132134

Właściwości

• Quality Segment: 100
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: do not freeze
• solubility: water: soluble
• shipped in: ambient
• storage temp.: 2-8°C

Opis

General description

Shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2. Cytopathic for a number of cell lines and exhibits toxicity in animals. Has enzymatic activity identical to that of diphtheria toxin, however it has distinct target-cell specificities and is immunologically unrelated.

Shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2. Cytopathic for a number of cell lines and exhibits toxicity in animals. Has enzymatic activity identical to that of diphtheria toxin; however, it has distinct target-cell specificity and is immunologically unrelated.

Biochem/physiol Actions

Cell permeable: no

Primary Target
ADP-ribosylation of elongation factor 2

Product does not compete with ATP.

Reversible: no

Physical form

Solid lyophilized from 150 mM NaCl, 10 mM sodium phosphate buffer, pH 7.5.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 6 months at -20°C.

Analysis Note

Single band by SDS-PAGE; single precipitin band by immunodiffusion

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Prentice, G.A., and Merrill, A.R. 1999. Anal. Biochem. 272, 216.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials