251600

Daidzein

Inactive analog of Genistein.

• Synonim(y): Daidzein, 4ʹ,7-Dihydroxyisoflavone, Casein Kinase II Inhibitor X
• Wzór empiryczny (zapis Hilla): C₁₅H₁₀O₄
• Numer CAS: 486-66-8
• Masa cząsteczkowa: 254.24
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00016954
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Właściwości

• Quality Segment: 100
• description: Merck USA index - 14, 2801
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O1c2c(ccc(c2)O)C(=O)C(=C1)c3ccc(cc3)O
• InChI: 1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
• InChI key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N

Opis

General description

Inactive analog of Genistein (Cat. No. 345834). Blocks the G₁ phase of the cell cycle in Swiss/3T3 cells by inhibiting casein kinase II activity. Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC₅₀= 45 µM and 75 µM, respectively).

Inactive analog of genistein (Cat. No. 345834). Blocks the G₁ phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity. Inhibits epidermal growth factor (EGF) receptor autophosphorylation (IC₅₀ >300 µM). Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC₅₀= 45 µM and 75 µM, respectively).

Biochem/physiol Actions

Cell permeable: no

Primary Target
MiaPaC-2, PANC-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 45 µM, 75 µM for inhibiting the growth of MiaPaC-2 and PANC-1 cells, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. DMSO stock solutions are stable for up to 2 months at -20°C.

Other Notes

Guo, J-M., et al. 2004. World J. Gastroenterol.10, 860.
Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol.7, 637.
Akiyama, T., et al. 1987. J. Biol. Chem.262, 5592.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable