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171256

Aktywator AMPK

The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Synonim(y):

Kwas 5-(3-(4-(2-(4-fluorofenylo)etoksy)fenylo)propylo)furano-2-karboksylowy, D942, AMPK Signaling Activator I

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Do Państwa/SKUDostępnośćCena netto
5 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

850,00 zł
722,50 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C22H21FO4
Numer CAS:
849727-81-7
Masa cząsteczkowa:
368.40
MDL number:
MFCD23160261
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light

722,50 zł

Cena katalogowa850,00 złZaoszczędź 15%

Dostępne do wysyłki DZISIAJSzczegóły

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Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

light yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)CCOc2ccc(cc2)CCCc3[o]c(cc3)C(=O)O

InChI

1S/C22H21FO4/c23-18-8-4-17(5-9-18)14-15-26-19-10-6-16(7-11-19)2-1-3-20-12-13-21(27-20)22(24)25/h4-13H,1-3,14-15H2,(H,24,25)

InChI key

MPLLLQUZNJSVTK-UHFFFAOYSA-N

General description

A cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.

Biochem/physiol Actions

Cell permeable: yes
EC50 = 11.7 µM enhancing glucose uptake in L6 myocytes
Primary Target
AMPK
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kosaka, T., et al. 2005. Anal. Chem.77, 2050.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)
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Ta pozycja
346021550601171260
Aktywator AMPK The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sigma-Aldrich

171256

Aktywator AMPK

Glucokinase Activator, Cpd A The Glucokinase Activator, Cpd A, also referenced under CAS 603108-44-7, modulates Glucokinase. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sigma-Aldrich

346021

Glucokinase Activator, Cpd A

Pyruvate Kinase Activator The Pyruvate Kinase Activator controls the biological activity of Pyruvate Kinase. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sigma-Aldrich

550601

Pyruvate Kinase Activator

Inhibitor AMPK, związek C AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC50 = 25.1, 148, and 234.6 nM, respectively).

Sigma-Aldrich

171260

Inhibitor AMPK, związek C

description

The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

description

The Glucokinase Activator, Cpd A, also referenced under CAS 603108-44-7, modulates Glucokinase. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

description

The Pyruvate Kinase Activator controls the biological activity of Pyruvate Kinase. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

description

AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC50 = 25.1, 148, and 234.6 nM, respectively).

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

powder

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL

solubility

DMSO: 5 mg/mL

solubility

DMSO: 100 mg/mL, clear, colorless

solubility

2% HCl: 10 mg/mL, 2% acetic acid: 10 mg/mL, methanol: 3 mg/mL, DMSO: 4 mg/mL

Klasa składowania

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

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