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Dokumenty

07-164-AF647

Sigma-Aldrich

Anti-phospho H2A.X (Ser139) Antibody, Alexa Fluor™ 647 Conjugate

from rabbit, ALEXA FLUOR™ 647

Synonim(y):

Histone H2A.X, Histone H2A.X, H2a/x

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

100

białko sprzężone

ALEXA FLUOR™ 647

forma przeciwciała

purified antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

reaktywność gatunkowa

human

reaktywność gatunkowa (przewidywana na podstawie homologii)

vertebrates (based on 100% sequence homology)

metody

immunocytochemistry: suitable

izotyp

IgG

numer dostępu NCBI

NP_002096

numer dostępu UniProt

P16104

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

phosphorylation (pSer139)

informacje o genach

human ... ATP10D(57205) , H2AX(3014)

Opis ogólny

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. H2A.X, also known as H2AFX, is a variant of Histone H2A that is found in a subset of nucleosomes. H2A.X has a unique C-terminal tail that becomes phosphorylated following double-stranded DNA breaks following irradiation or apoptosis. Phosphorylation of H2A.X on Ser139 is one of the earliest markers for apoptosis and DNA damage.

Specyficzność

Recognizes Histone H2A.X phosphorylated at Serine 139.

Immunogen

Epitope: Phosphorylated Ser139
KLH-conjugated linear peptide corresponding to phospho H2A.X (Ser139).

Zastosowanie

Research Category
Epigenetics & Nuclear Function

Epigenetics & Nuclear Function
Research Sub Category
Histones

Chromatin Biology
See data sheet for cat# 07-164, Anti-phospho H2A.X (Ser139) for additional Western blot, Immnoprecipitation, and ChIP-seq analysis performed using an unconjugated version of this antibody.
This AlexaFluor647 conjugated Anti-phospho Histone H2A.X antibody is validated for use in mmunocytochemistry for the detection of phospho-Histone H2A.X.

Jakość

Immunocytochemistry Analysis:

A 1:100 dilution of this antibody detected phospho Histone H2A.X (Ser139) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.

Opis wartości docelowych

~15 kDa observed

Postać fizyczna

Protein A purified
Purified conjugated rabbit polyclonal antibody in buffer containing PBS and 15 mg/ml BSA with 0.1% Sodium Azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to lot specific datasheet.

Informacje prawne

ALEXA FLUOR is a trademark of Life Technologies

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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