D2388

Dimethyl 3,3′-dithiopropionimidate dihydrochloride

powder

• Synonim(y): DTBP, Dimethyl 3,3′-dithio-bis(propionimidate) dihydrochloride, Wang/Richards’ reagent
• Wzór empiryczny (zapis Hilla): C₈H₁₆N₂O₂S₂ · 2HCl
• Numer CAS: 38285-78-8
• Masa cząsteczkowa: 309.28
• NACRES: NA.22
• PubChem Substance ID: 57654084
• UNSPSC Code: 12352116
• MDL number: MFCD00043245
• Form: powder

Właściwości

• form: powder
• reaction suitability: reagent type: cross-linking reagent
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.COC(=N)CCSSCCC(=N)OC
• InChI: 1S/C8H16N2O2S2.2ClH/c1-11-7(9)3-5-13-14-6-4-8(10)12-2;;/h9-10H,3-6H2,1-2H3;2*1H
• InChI key: CQBCVFHLZAVNPF-UHFFFAOYSA-N

Opis

Application

A homobifunctional, cleavable cross-linking reagent. Typically, reacted with primary amines in the pH range 7.0-10.0 to form amidine bonds.

Reactant for:

• Synthesis of glutathione-sensitive cross-linked polyethylenimine gene vector
• Preparation of cyclodextrin-containing polymers designed for gene delivery
• Crosslinking of chick oviduct progesterone-receptor subunits

Other Notes

Note that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker.

Disclaimer

The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315
• Hazard Classifications: Skin Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves