925012

E7820-PEG₅-NH₂ hydrochloride

• Synonim(y): N-(17-amino-3,6,9,12,15-pentaoxaheptadecyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, DCAF15 protein degrader building block
• Wzór empiryczny (zapis Hilla): C₂₉H₃₉N₅O₈S · xHCl
• Masa cząsteczkowa: 617.71 (free base basis)
• NACRES: NA.22
• UNSPSC Code: 12352200

Właściwości

• ligand: E7820
• Quality Segment: 100
• reaction suitability: reactivity: carboxyl reactive, reagent type: ligand-linker conjugate
• technique(s): targeted protein degradation: suitable
• functional group: amine
• storage temp.: 2-8°C

Opis

Application

Protein degrader builiding block E7820-PEG5-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation

Other Notes

Protein Degrader Building Blocks

In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable