923397

1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)azetidine-3-carboxylic acid

• Synonim(y): Rigid linker for PROTAC^® development
• Wzór empiryczny (zapis Hilla): C₁₆H₂₆N₂O₅
• Masa cząsteczkowa: 326.39
• MDL number: MFCD34674294
• UNSPSC Code: 12352106
• NACRES: NA.22

Właściwości

• form: powder
• Quality Segment: 100
• reaction suitability: reagent type: linker
• technique(s): targeted protein degradation: suitable
• functional group: Boc, carboxylic acid
• storage temp.: 2-8°C
• SMILES string: O=C(O)C1CN(C1)CC(CC2)OC32CN(C(OC(C)(C)C)=O)C3
• InChI: 1S/C16H26N2O5/c1-15(2,3)23-14(21)18-9-16(10-18)5-4-12(22-16)8-17-6-11(7-17)13(19)20/h11-12H,4-10H2,1-3H3,(H,19,20)
• InChI key: XRGOUJDVCBSCAE-UHFFFAOYSA-N

Opis

Application

1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)azetidine-3-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Developed in partnership with ComInnex.

Similar linkers in this series:
923389


923354

Other Notes

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable