798428

Endo-2-Naphthyl Kwon [2.2.1] Bicyclic Phosphine

• Synonim(y): (1S,4S,5S)-5-(naphthalen-2-yl)-2-tosyl-2-aza-5-phosphabicyclo[2.2.1]heptane
• Wzór empiryczny (zapis Hilla): C₂₂H₂₂NO₂PS
• Masa cząsteczkowa: 395.45
• PubChem Substance ID: 329768648
• UNSPSC Code: 12352000

Właściwości

• form: powder
• functional group: phosphine, sulfonamide
• storage temp.: 2-8°C
• SMILES string: O=S(N1C[C@H]2[P@@](C3=CC=C(C=CC=C4)C4=C3)C[C@@H]1C2)(C5=CC=C(C)C=C5)=O
• InChI: 1S/C22H22NO2PS/c1-16-6-10-22(11-7-16)27(24,25)23-14-21-13-19(23)15-26(21)20-9-8-17-4-2-3-5-18(17)12-20/h2-12,19,21H,13-15H2,1H3
• InChI key: SJQXCVUHXMHJMD-UHFFFAOYSA-N

Opis

Application

The bicyclic, chiral phosphine was developed by the Kwon Research Group.Its initial applications were for asymmetric [3+2] annulation between allenes and imines as well as the first examples of phosphine-catalyzed asymmetric syntheses of 1,2,3,5-substituted pyrrolines. Along with nucleophilic organocatalysis, the P-chiral phosphines may also find utility in asymmetric transition-metal catalysis.

Other Notes

Hydroxyproline-Derived Pseudoenantiomeric [2.2.1] Bicyclic Phosphines: Asymmetric Synthesis of (+)- and (-)-Pyrrolines

Technology Spotlight- Kwon Phosphines: P-Chiral Monodentate Phosphines from Hydroxyproline

Aldrichimica Acta Review- Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric Annulations

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable