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764019

Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester

≥90%

Synonim(y):

DBCO-PEG4-NHS ester, DBCO-PEG4-SE, DBCO-PEG4-succinimidyl ester

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Rozmiar/SKUDostępnośćCena netto
1 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
198,00 zł
5 mg
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
618,00 zł
50 mg
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2670,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C34H39N3O10
Masa cząsteczkowa:
649.69
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352108
MDL number:
Assay:
≥90%
Form:
paste

198,00 zł


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Quality Segment

assay

≥90%

form

paste

reaction suitability

reaction type: click chemistry, reagent type: linker

functional group

NHS ester

storage temp.

−20°C

SMILES string

O=C(CCC(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI

1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38)

InChI key

RRCXYKNJTKJNTD-UHFFFAOYSA-N

Application

Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester may be used in the synthesis of a prostate-specific membrane antigen (PSMA)-targeted single photon emission computed tomography (SPECT) agent via copper-less click chemistry.
Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:
  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification
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Ta pozycja
761524761540760668
description

≥90%

description

for Copper-free Click Chemistry

description

for Copper-free Click Chemistry

description

for Copper-free Click Chemistry

assay

≥90%

assay

-

assay

≥94.5 %

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

reaction suitability

reaction type: click chemistry, reagent type: linker

reaction suitability

reagent type: cross-linking reagent, reaction type: click chemistry

reaction suitability

reaction type: click chemistry, reagent type: linker

reaction suitability

reagent type: cross-linking reagent, reaction type: click chemistry

form

paste

form

solid

form

solid

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

functional group

NHS ester

functional group

NHS ester

functional group

amine

functional group

maleimide


Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Hi I would like to know if the extinction coefficient value of this molecule available. Thanks

    1 answer
    1. There is no published value for the extinction coefficient of this molecule.

      Helpful?

  4. Hi. Is this product stable at 4 degrees for a few days? Thanks

    1 answer
    1. The storage temperature is deliberately conservative for long term storage and is set at -20°C for this item. Unfortunately, storage at alternate conditions such as 4°C have not been assessed for this product.

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