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532282
2-Chlorotrityl chloride, polymer-bound
200-400 mesh, extent of labeling: 0.3-0.8 mmol/g Cl loading, 2 % cross-linked
Synonim(y):
2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene
Wybierz wielkość
| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
5 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1830,00 zł |
Informacje o tej pozycji
1830,00 zł
Quality Segment
crosslinking
2 % cross-linked
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
extent of labeling
0.3-0.8 mmol/g Cl loading
particle size
200-400 mesh
application(s)
peptide synthesis
SMILES string
Clc1ccccc1C(Cl)(c2ccccc2)c3ccccc3
InChI
1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChI key
JFLSOKIMYBSASW-UHFFFAOYSA-N
Application
- Acid labile resin used in Fmoc-based solid phase peptide synthesis.
- Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
- 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
- This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences.
Use:
- Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
- Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
- Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
- If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.
1 of 1
Ta pozycja | |||
|---|---|---|---|
| description 200-400 mesh, extent of labeling: 0.3-0.8 mmol/g Cl loading, 2 % cross-linked | description 200-400 mesh, extent of labeling: 1.0-1.5 mmol/g Cl loading, 1 % cross-linked | description ≥97.0% (AT) | description certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
| application(s) peptide synthesis | application(s) peptide synthesis | application(s) - | application(s) pharmaceutical |
| crosslinking 2 % cross-linked | crosslinking 1 % cross-linked | crosslinking - | crosslinking - |
| particle size 200-400 mesh | particle size 200-400 mesh | particle size - | particle size - |
| extent of labeling 0.3-0.8 mmol/g Cl loading | extent of labeling 1.0-1.5 mmol/g Cl loading | extent of labeling - | extent of labeling - |
| reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability - | reaction suitability - |
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Słowo ostrzegawcze
Warning
Kody zagrożeń
Hazard Classifications
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
Narządy docelowe
Respiratory system
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
PPE (środki ochrony indywidualnej)
dust mask type N95 (US), Eyeshields, Gloves
Klasa składowania
11 - Combustible Solids
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