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Merck

MME

membrane metallo-endopeptidase

Synonimy:
CALLA, CD10, NEP, SFE
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(4311) Summary: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
  • Mouse(17380) membrane metallo endopeptidase
  • Rat(24590) membrane metallo-endopeptidase
  • chicken(425031) membrane metallo-endopeptidase
  • dog(477120) membrane metallo-endopeptidase
  • Horse(100053541) membrane metallo-endopeptidase
  • domestic cat(101087516) membrane metallo-endopeptidase
  • sheep(101112618) membrane metallo-endopeptidase
  • cow(536741) membrane metallo-endopeptidase
  • Domestic Rabbit(100009251) membrane metallo-endopeptidase
  • naked mole-rat(101715828) membrane metallo-endopeptidase
  • domestic guinea pig(100724320) membrane metallo-endopeptidase

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ELISA

Numer produktu
Opis
Gatunek
Mouse Mme / Neprilysin ELISA Kit, ,
Gatunek
mouse
Human MME / Neprilysin ELISA, ,
Gatunek
human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Monoclonal Anti-CD10 PE-Cyanine7 produced in mouse, ,
Reaktywność gatunkowa
human
Zastosowanie
flow cytometry
Monoclonal Anti-CD10 APC-Cyanine7 produced in mouse, ,
Reaktywność gatunkowa
human
Zastosowanie
flow cytometry
Anti-Neprilysin/CD10 Antibody, clone 1C22 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
affinity binding assay
flow cytometry

immunocytochemistry

immunohistochemistry

western blot
Monoclonal Anti-CD10-FITC antibody produced in mouse, clone MEM-78, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
flow cytometry
Monoclonal Anti-CD10 antibody produced in mouse, clone LT10, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
flow cytometry

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine, 97%,
Gatunek
human, mouse, rat
DL-Thiorphan, ≥98% (TLC),
Gatunek
human, rat

Proteins

Numer produktu
Opis
Gatunek
Neprilysin/CD10 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting mouse Mme,
Gatunek
mouse
MISSION® esiRNA, targeting human MME,
Gatunek
human