V2257

[deamino-Cys¹, D-3-Pyridyl-Ala², Arg⁸]-Vasopressin

≥97% (HPLC)

• Synonym(s): D3PVP
• Empirical Formula (Hill Notation): C₄₅H₆₃N₁₅O₁₁S₂
• CAS Number: 136105-89-0
• Molecular Weight: 1054.21
• UNSPSC Code: 51111800
• PubChem Substance ID: 24900730
• MDL number: MFCD00214667

Properties

• assay: ≥97% (HPLC)
• form: solid
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: NC(=N)NCCCC(NC(=O)C1CCCN1C(=O)C2CSSCCC(=O)NC(Cc3cccnc3)C(=O)NC(Cc4ccccc4)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N2)C(=O)NCC(N)=O
• InChI: 1S/C45H63N15O11S2/c46-34(61)13-12-28-39(66)58-31(21-35(47)62)42(69)59-32(44(71)60-17-6-11-33(60)43(70)56-27(10-5-16-52-45(49)50)38(65)53-23-36(48)63)24-73-72-18-14-37(64)54-29(20-26-9-4-15-51-22-26)40(67)57-30(41(68)55-28)19-25-7-2-1-3-8-25/h1-4,7-9,15,22,27-33H,5-6,10-14,16-21,23-24H2,(H2,46,61)(H2,47,62)(H2,48,63)(H,53,65)(H,54,64)(H,55,68)(H,56,70)(H,57,67)(H,58,66)(H,59,69)(H4,49,50,52)
• InChI key: KEAHYTRPVNOHKL-UHFFFAOYSA-N
• Gene Information: human ... AVPR1B(553) ; mouse ... AVPR1B(26361) ; rat ... AVPR1B(29462)

Description

Application

[Deamino-Cys¹, D-3-Pyridyl-Ala², Arg⁸]-Vasopressin is a V1b specific receptor agonist was used to examine vasopressin receptor types involved in regulation of COX expression in BB rats.

Biochem/physiol Actions

[Deamino-Cys1, D-3-Pyridyl-Ala2, Arg8]-Vasopressin also referred to as D3PVP is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pHi.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H332
• Hazard Classifications: Acute Tox. 4 Inhalation
• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves