T5651

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

• Synonym(s): Fugu poison, Maculotoxin, TTX, Tarichatoxin
• Empirical Formula (Hill Notation): C₁₁H₁₇N₃O₈
• CAS Number: 4368-28-9
• Molecular Weight: 319.27
• Beilstein: 49176
• MDL number: MFCD00213719
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900308

Properties

• form: powder
• availability: not available in USA
• pH: 4.8
• solubility: H₂O: soluble (stable at pH 4-5 if stored frozen); strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
• storage temp.: 2-8°C
• SMILES string: OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O
• InChI: 1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
• InChI key: CFMYXEVWODSLAX-IXUBDLNJSA-N
• Gene Information: rat ... Scnn1g(24768)

Description

Application

Tetrodotoxin has been used to study its effects on microglial functions in rats². This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway³.

Biochem/physiol Actions

Reversible, selective blocker of Na⁺ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Packaging

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Preparation Note

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 1 Oral
• Storage Class Code: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable