This compound is soluble in DMSO (> 10mg/ml).
T3077
TRO 19622
≥98% (HPLC), solid
Synonym(s):
Cholest-4-en-3-one, oxime, NSC 21311, Olesoxime
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | PLN 646.00 PLN 549.10 |
About This Item
Empirical Formula (Hill Notation):
C27H45NO
CAS Number:
Molecular Weight:
399.65
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
PLN 549.10
List PricePLN 646.00Save 15%Please contact Customer Service for Availability
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
InChI
1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+
InChI key
QNTASHOAVRSLMD-SGWCAAJKSA-N
Application
TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.
Biochem/physiol Actions
TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.
TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).
Preparation Note
TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >10 mg/mL | solubility DMSO: 3 mg/mL, clear (warmed) | solubility H2O: 10 mg/mL≥ | solubility DMSO: soluble 13 mg/mL |
| color white | color white to beige | color white to off-white | color - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the solubility of TRO 19622, Product T3077?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the structure of TRO 19622, Product T3077?
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Please see the following reference for more information: T. Bordet et al., Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J. Pharmacol. Exp. Ther., 322, 709-720 (2007).
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How does TRO 19622, Product T3077 work?
1 answer-
TRO 19622 interacts with the mitochondrial permeability transition pore (mPTP). By interacting with protein components of the mPTP, it prevents the release of apoptotic factors and therefore protects the neuron. This mechanism of action may lead to a general neuroprotective activity. Please see the following reference for more information: T. Bordet et al., Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis J. Pharmacol. Exp. Ther. 322, 709-720, (2007)
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