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SML2295

Sigma-Aldrich

Dimethyoxy-etomidate

≥98% (HPLC)

Synonym(s):

(R)-ethyl 1-(1-(3,5-dimethoxyphenyl)ethyl)-1H-imidazole-5-carboxylate

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5 MG
PLN 323.00
25 MG
PLN 1,310.00

PLN 323.00

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5 MG
PLN 323.00
25 MG
PLN 1,310.00

About This Item

Empirical Formula (Hill Notation):
C16H20N2O4
CAS Number:
2300142-82-7
Molecular Weight:
304.34
UNSPSC Code:
12352200

PLN 323.00

Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥98% (HPLC)

form

oil

color

colorless to light brown

storage temp.

2-8°C

SMILES string

C[C@@H](N1C=NC=C1C(OCC)=O)C2=CC(OC)=CC(OC)=C2

InChI

1S/C16H20N2O4/c1-5-22-16(19)15-9-17-10-18(15)11(2)12-6-13(20-3)8-14(7-12)21-4/h6-11H,5H2,1-4H3/t11-/m1/s1

InChI key

JETTTZITBCWAQX-LLVKDONJSA-N

Biochem/physiol Actions

Dimethyoxy-etomidate is a phenyl ring substituted etomidate analog.[1]
Dimethyoxy-etomidate is a potent suppressor of adrenocortical steroid synthesis by inhibiting steroid 11β-hydroxylase. Dimethyoxy-etomidate is essentially divided of etomidate′s GABAA receptor positive modulatory and sedative-hypnotic activities.
potent suppressor of adrenocortical steroid synthesis, selective inhibitor of steroid 11β-hydroxylase

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000056734
0000056735
0000040036

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Megan McGrath et al.
The Journal of pharmacology and experimental therapeutics, 364(2), 229-237 (2017-12-06)
Cushing's syndrome is characterized by the overproduction of adrenocortical steroids. Steroidogenesis inhibitors are mainstays of medical therapy for Cushing's syndrome; unfortunately, adverse side effects and treatment failures are common with currently available drugs. The general anesthetic induction agent etomidate is
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
McGrath M, et al.
BMC Pharmacology & Toxicology, 20, 1-9 (2019)

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