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SML1121

Sigma-Aldrich

SB743921 hydrochloride

≥98% (HPLC)

Synonym(s):

N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C31H33ClN2O3 · HCl
CAS Number:
940929-33-9
Molecular Weight:
553.52
MDL number:
MFCD18385010
UNSPSC Code:
12352200
PubChem Substance ID:
329825661
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

−20°C

SMILES string

CC(C)[C@@H](N(CCCN)C(C1=CC=C(C)C=C1)=O)C2=C(CC3=CC=CC=C3)C(C4=C(O2)C=C(Cl)C=C4)=O.Cl

InChI

1S/C31H33ClN2O3.ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30;/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3;1H/t28-;/m1./s1

InChI key

MLMZVWABFOLFGV-LNLSOMNWSA-N

Biochem/physiol Actions

SB743921 is an inhibitor of kinesin spindle protein (KSP) with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4, and CENP-E.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Mehdi Bouhaddou et al.
Cell, 182(3), 685-712 (2020-07-10)
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a

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Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

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