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SML0551

Icaritin

≥98% (HPLC)

Synonym(s):

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

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Pack SizeSKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
PLN 534.00
25 mg
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PLN 2,150.00
PLN 1,827.50

About This Item

Empirical Formula (Hill Notation):
C21H20O6
CAS Number:
118525-40-9
Molecular Weight:
368.38
NACRES:
NA.77
PubChem Substance ID:
329825547
UNSPSC Code:
12352200
MDL number:
MFCD22422519
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

PLN 534.00

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

light yellow to dark yellow

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)c(C\C=C(\C)C)c3O2

InChI

1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3

InChI key

TUUXBSASAQJECY-UHFFFAOYSA-N

Biochem/physiol Actions

Icaritin enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs.
Icaritin enhances osteoblastic differentiation of mesenchymal stem cells (MSCs). It may have estrogen-like activities.
Icaritin is a component of Epimedium flavonoid isolated from Herba Epimedii, which enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway. Icaritin has no effect on MSCs proliferation. Also, icaritin potently inhibits chronic myeloid leukemia (CML) and breast cancer cells proliferation most likely by modulation of MAPK/ERK/JNK and JAK2/STAT3 /AKT signaling. As other flavonoids, icaritin may exert estrogen-like activities.

Features and Benefits

This compound is featured on the JAKs, MAPKs and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
PHL89714PHL8047856601
Icaritin ≥98% (HPLC)

Sigma-Aldrich

SML0551

Icaritin

Icariin phyproof® Reference Substance

PHL89714

Icariin

Icaritin phyproof® Reference Substance

PHL80478

Icaritin

Icariin analytical standard

Supelco

56601

Icariin

assay

≥98% (HPLC)

assay

≥90.0% (HPLC)

assay

≥95.0% (HPLC)

assay

≥95% (HPLC)

form

powder

form

powder

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

-

solubility

-

solubility

-

color

light yellow to dark yellow

color

-

color

-

color

-

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000161289
0000161289
0000161290
0000129555

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Articles

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

Jian feng Zhu et al.
PloS one, 6(8), e23720-e23720 (2011-09-03)
To explore the effects of Icaritin on chronic myeloid leukemia (CML) cells and underlying mechanisms. CML cells were incubated with various concentration of Icaritin for 48 hours, the cell proliferation was analyzed by MTT and the apoptosis was assessed with
Haibang Hao et al.
European journal of immunology, 49(12), 2235-2244 (2019-08-30)
Icaritin, a hydrolytic product of icariin isolated from traditional Chinese herbal medicine genus Epimedium, has many pharmacological and biological activities. Here, we show that icaritin can effectively decrease tumor burden of murine B16F10 melanoma and MC38 colorectal tumors in a
Dong Yao et al.
PloS one, 7(8), e41264-e41264 (2012-09-07)
We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation of mesenchymal stem cells (MSCs) only under osteogenic induction conditions. We also demonstrated its effect on inhibition of adipogenic differentiation of MSCs. Unlike the findings of
View All Related Papers

Global Trade Item Number

SKUGTIN
SML0551-25MG04061832633817
SML0551-5MG04061832633824

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