SML0023

5-Iodo-A-85380 dihydrochloride hydrate

≥98% (HPLC)

• Synonym(s): 3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate
• Empirical Formula (Hill Notation): C₉H₁₁IN₂O · 2HCl · xH₂O
• CAS Number: 213550-82-4
• Molecular Weight: 363.02 (anhydrous basis)
• MDL number: MFCD20488048
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825095
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥22 mg/mL
• storage temp.: −20°C
• SMILES string: O.Cl.Cl.Ic1cncc(OC[C@@H]2CCN2)c1
• InChI: 1S/C9H11IN2O.2ClH.H2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8;;;/h3-5,8,12H,1-2,6H2;2*1H;1H2/t8-;;;/m0.../s1
• InChI key: DCVONLXGZUKNSI-CZDIJEQGSA-N

Description

Application

5-Iodo-A-85380 dihydrochloride hydrate may be used in nicotinic acetylcholine receptor-mediated signaling studies.

Biochem/physiol Actions

5-Iodo-A-85380 increases the influx of extracellular Ca⁺² in rat cortical neurons and exhibits protective effects against glutamate-induced neurotoxicity. Studies reveal that it also activates α6β2 nicotinic acetylcholine receptors.

5-Iodo-A-85380 is a highly selective α4β2 nicotinic receptor agonist. The K_i values for binding to the human and rat receptors are 12 and 10 pM, respectively.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H318
• Precautionary Statements: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable