SMB00379

Schisantherin A

≥98% (HPLC)

• Synonym(s): Gomisin C, Schizantherin A, Wuweizi ester A
• Empirical Formula (Hill Notation): C₃₀H₃₂O₉
• CAS Number: 58546-56-8
• Molecular Weight: 536.57
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824980
• NACRES: NA.25

Properties

• Assay: ≥98% (HPLC)
• form: powder
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: CC1(O)C(C)CC2=CC(OCO3)=C3C(OC)=C2C4=C(C=C(OC)C(OC)=C4OC)C1OC(C5=CC=CC=C5)=O
• InChI: 1S/C30H32O9/c1-16-12-18-13-21-25(38-15-37-21)26(35-5)22(18)23-19(14-20(33-3)24(34-4)27(23)36-6)28(30(16,2)32)39-29(31)17-10-8-7-9-11-17/h7-11,13-14,16,28,32H,12,15H2,1-6H3
• InChI key: UFCGDBKFOKKVAC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Schisantherin A is a lignan isolated from the fruits of Schisandra chinesi.

Schisantherin A is a mechanism-based inhibitor that competitively inhibits and irreversibly inactivates CYP3A4.
Schisantherin A (StA) has neuroprotective activity and could be potential candidate for the treatment of neuron loss in neurodegenerative diseases including Parkinson′s disease. It inhibits tumor progression and could be a potential drug target for cancer treatment. StA blocks ATP-binding cassette transporters and restores the levels of anti-cancer drugs in cancer cells. It also has anti-inflammatory property.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable