CDCA5 (cell division cycle associated 5) gene is mapped to human chromosome 11q13.1. The gene codes for the protein sororin. The protein is localized in the nucleus. It is known to be conserved among the vertebrates.
Immunogen
CDCA5 (NP_542399.1, 1 a.a. ~ 252 a.a) full-length human protein.
Sororin regulates proper cohesion and separation of sister chromatids during replication, by stabilizing cohesin on DNA. Phosphorylation of sororin by cyclin B during mitosis, reduces its potential to prevent Wap1 (cohesin release factor) and Pds5 (cohesin-interacting protein) binding.
Physical form
Solution in phosphate buffered saline, pH 7.4
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C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion.
Zhang N and Pati D
Cell Cycle, 14(6), 820-826 (2015)
Genomic alterations identified by array comparative genomic hybridization as prognostic markers in tamoxifen-treated estrogen receptor-positive breast cancer.
Han W
BMC Cancer, 6:92, 1-13 (2006)
Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion.
Zhang N.
The Journal of Biological Chemistry, 286(48), 41826-41837 (2011)
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