S8951

SR11237

Name: SR11237
Brand: SIGMA
Price: 583 PLN

≥98% (HPLC)

Synonym(s):

4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid, BMS 188649, BMS649

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5 MG

PLN 583.00

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PLN 2,260.00

PLN 583.00

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₈O₄

CAS Number:

146670-40-8

Molecular Weight:

380.48

NACRES:

NA.77

PubChem Substance ID:

329824615

UNSPSC Code:

12352200

MDL number:

MFCD00864137

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >28 mg/mL (warmed)

storage temp.

2-8°C

SMILES string

CC1(C)CCC(C)(C)c2cc(ccc12)C3(OCCO3)c4ccc(cc4)C(O)=O

InChI

1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)

InChI key

ZZUKALQMHNSWTK-UHFFFAOYSA-N

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Show Differences

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This Item	SML2015	SML0397	SML0282
Sigma-Aldrich S8951 SR11237	Sigma-Aldrich SML2015 MM11253	Sigma-Aldrich SML0397 DR2313	Sigma-Aldrich SML0282 Bexarotene
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: >28 mg/mL (warmed)	solubility DMSO: 2 mg/mL, clear	solubility H₂O: >2 mg/mL (warmed)	solubility DMSO: ≥15 mg/mL (warmed)
color white to off-white	color white to beige	color white to beige	color white to beige

Application

SR11237 may be used in RXR-mediated cell signaling studies.

Biochem/physiol Actions

SR11237 and other ligands of retinoid X receptor (RXR) activate various nuclear receptors during development process. This produces malformations in Xenopus embryos, involving the anterior-posterior axis.¹

SR11237 is a pan retinoid X receptor (RXR) agonist.

SR11237 is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Endogenous retinoid X receptors can function as hormone receptors in pituitary cells.

K D Davis et al.

Molecular and cellular biology, 14(11), 7105-7110 (1994-11-01)

Retinoids regulate gene transcription by interacting with both retinoic acid (RA) receptors (RARs) and retinoid X receptors (RXRs). Since unliganded RXRs can act as heterodimerization partners for RARs and other nuclear hormone receptors, it is unclear whether ligand binding by

Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.

S Minucci et al.

Proceedings of the National Academy of Sciences of the United States of America, 93(5), 1803-1807 (1996-03-05)

Retinoids exert pleiotropic effects on the development of vertebrates through the action of retinoic acid receptors (RAR) and retinoid X receptors (RXR). We have investigated the effect of synthetic retinoids selective for RXR and RAR on the development of Xenopus

Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt.

Sarah E Walker et al.

Neural regeneration research, 13(6), 1036-1045 (2018-06-22)

Some adult vertebrate species, such as newts, axolotls and zebrafish, have the ability to regenerate their central nervous system (CNS). However, the factors that establish a permissive CNS environment for correct morphological and functional regeneration in these species are not

[Effect of retinoid X receptor activation on oxidized low-density lipoprotein induced cell differentiation of murine macrophage cell line into dendritic like cells].

Ling-hong Shen et al.

Zhonghua xin xue guan bing za zhi, 35(9), 833-837 (2007-12-12)

To investigate the effect and related mechanism of retinoid X receptor (RXR) activation on oxidized low-density lipoprotein (ox-LDL) induced differentiation of macrophage into dendritic cell. RAW264.7 murine macrophage cell line was cultured with ox-LDL for 48 h in the absence

Differentiation of myeloid cell lines correlates with a selective expression of RIZ protein.

P Gazzerro et al.

Molecular medicine (Cambridge, Mass.), 7(8), 552-560 (2001-10-10)

The retinoblastoma-interacting zinc-finger gene RIZ is expressed in two forms (RIZ1 and RIZ2) that differ for the presence near the N-terminus of RIZ1 of a conserved domain, defined PR (PRDI-BF1-RIZ homology), homologous to a similar domain present in other proteins

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Global Trade Item Number

SKU	GTIN
S8951-5MG	04061832954691
S8951-25MG	04061832954684

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SR11237