S8567

SU 4312

≥98% (HPLC)

• Synonym(s): 3-(4-Dimethylaminobenzylidenyl)-2-indolinone, 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
• Empirical Formula (Hill Notation): C₁₇H₁₆N₂O
• CAS Number: 5812-07-7
• Molecular Weight: 264.32
• NACRES: NA.77
• PubChem Substance ID: 24278803
• UNSPSC Code: 51111800
• MDL number: MFCD00118147
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: orange
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23
• InChI: 1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+
• InChI key: UAKWLVYMKBWHMX-RVDMUPIBSA-N
• Gene Information: human ... FLT1(2321)

Description

Application

SU 4312 was used to study angiogenesis during development of zebrafish embryos.²

Biochem/physiol Actions

SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.¹

SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves