S7947

Stattic

≥98% (HPLC), STAT3 activation inhibitor, powder

• Synonym(s): 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
• Empirical Formula (Hill Notation): C₈H₅NO₄S
• CAS Number: 19983-44-9
• Molecular Weight: 211.19
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824592
• NACRES: NA.77
• MDL number: MFCD00173799
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Stattic, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >20 mg/mL
• SMILES string: [O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
• InChI: 1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
• InChI key: ZRRGOUHITGRLBA-UHFFFAOYSA-N

Description

Application

Stattic has been used to inhibit signal transducer and activator of transcription 3 (STAT3) activity in various cell lines and culture.

Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.⁵

Biochem/physiol Actions

Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.² Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,³ and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.⁴

Stattic is an irreversible STAT3 activation inhibitor.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves