S4069

SL327

≥98% (HPLC), Mixture of E & Z isomers, solid

• Synonym(s): α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327
• Empirical Formula (Hill Notation): C₁₆H₁₂F₃N₃S
• CAS Number: 305350-87-2
• Molecular Weight: 335.35
• NACRES: NA.77
• PubChem Substance ID: 329824537
• UNSPSC Code: 12352200
• MDL number: MFCD06411432
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, protect from light

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, protect from light
• color: white to off-white
• mp: 127-128.2 °C
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
• InChI: 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
• InChI key: JLOXTZFYJNCPIS-FYWRMAATSA-N

Description

Application

SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos[1] and lymphatic endothelial cell (LEC).[2]

SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats.[3] It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.[4]

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro.

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)