The donor pool size varies from lot to lot. Historical data indicates that the raw material is typically derived from a pool of 12 - 15 donors.
S1764
Complement sera human
lyophilized powder
Synonym(s):
Human Serum Complement
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1 ML
PLN 544.00
5 X 1 ML
PLN 1,910.00
About This Item
Biological source:
human
Origin:
USA origin
Form:
lyophilized powder
Shipped in:
dry ice
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biological source
human
Quality Level
form
lyophilized powder
origin
USA origin
technique(s)
cell culture | mammalian: suitable
impurities
virus, tested
shipped in
dry ice
storage temp.
−20°C
1 of 4
This Item | |||
|---|---|---|---|
| biological source human | biological source mouse | biological source human | biological source rabbit |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | embryo: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | embryo: suitable, cell culture | mammalian: suitable |
| form lyophilized powder | form lyophilized powder | form - | form lyophilized powder |
| origin USA origin | origin - | origin USA origin | origin - |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| impurities virus, tested | impurities - | impurities (mycoplasma tested, virus tested), ≤10 EU/mL endotoxin | impurities - |
General description
Complement serum is prepared from pooled human plasma and lyophilized from the amount of serum indicated on the label.
Application
Complement sera human has been used:
- to incubate DLD-1 or SW-620 cells to quantify C5a release
- in multiplex bead antibody-binding assay to assay C3d
- in complement-dependent cytotoxicity assay
Complement sera human has been used:
- to incubate DLD-1 or SW-620 cells to quantify C5a release[1]
- in multiplex bead antibody-binding assay to assay C3d[2]
- in complement-dependent cytotoxicity assay[3]
The activity of complement sera can be determined by hemolytic assays in vitro. [4]
Physical form
Lyophilized powder from indicated amount of serum
Analysis Note
Hemolytic titer (CH50 units per ml) is determined by method of Kabat and Mayer. Actual titer given on label.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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David A Spencer et al.
Nature communications, 13(1), 662-662 (2022-02-05)
Increasingly, antibodies are being used to treat and prevent viral infections. In the context of HIV, efficacy is primarily attributed to dose-dependent neutralization potency and to a lesser extent Fc-mediated effector functions. It remains unclear whether augmenting effector functions of
Harini Natarajan et al.
mBio, 12(2) (2021-04-22)
Convalescent plasma is a promising therapy for coronavirus disease 2019 (COVID-19), but the antibody characteristics that contribute to efficacy remain poorly understood. This study analyzed plasma samples from 126 eligible convalescent blood donors in addition to 15 naive individuals, as
Lisa Tomasi et al.
Open forum infectious diseases, 9(11), ofac554-ofac554 (2022-12-06)
The basis of the less severe clinical presentation of coronavirus disease 2019 (COVID-19) in children as compared with adults remains incompletely understood. Studies have suggested that a more potent boosting of immunity to endemic common cold coronaviruses (HCoVs) may protect
Helen Kotanides et al.
Cancer immunology research, 8(10), 1300-1310 (2020-09-03)
The programmed cell death protein 1 receptor (PD-1) and programmed death ligand 1 (PD-L1) coinhibitory pathway suppresses T-cell-mediated immunity. We hypothesized that cotargeting of PD-1 and PD-L1 with a bispecific antibody molecule could provide an alternative therapeutic approach, with enhanced
Savannah E Butler et al.
Frontiers in immunology, 11, 618685-618685 (2021-02-16)
Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role in the development of vaccines and antibody-based interventions. We report systemic and mucosal antibody responses in convalescent individuals who experienced varying severity of disease. Whereas assessment of neutralization
Related Content
Datasheet
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S1764-1ML | 04061836913861 |
| S1764-5X1ML | 04061836913960 |
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