S1437

Sex Hormone-Binding Globulin from human serum

≥95% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(s): SHBG, Testosterone-estradiol binding globulin
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00163748
• Form: buffered aqueous glycerol solution
• Assay: ≥95% (SDS-PAGE)
• Biological source: human serum

Properties

• biological source: human serum
• Quality Segment: 200
• assay: ≥95% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• technique(s): cell culture | mammalian: suitable
• UniProt accession no.: P04278
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... SHBG(6462)

Description

General description

Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.

Application

Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.

Biochem/physiol Actions

Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.

Physical form

Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable