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S1318

STO-609-acetic acid

≥95% (HPLC), solid

Synonym(s):

7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid - acetic acid

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
PLN 1,140.00
PLN 969.00

About This Item

Empirical Formula (Hill Notation):
C19H10N2O3 · C2H4O2
CAS Number:
1173022-21-3
Molecular Weight:
374.35
NACRES:
NA.77
PubChem Substance ID:
329824472
UNSPSC Code:
12352106
MDL number:
MFCD06411456
Assay:
≥95% (HPLC)
Form:
solid

PLN 969.00

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assay

≥95% (HPLC)

form

solid

mp

>300 °C

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC(O)=O.OC(=O)c1ccc2-c3nc4ccccc4n3C(=O)c5cccc1c25

InChI

1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)

InChI key

WNRSTFUVBWNELX-UHFFFAOYSA-N

General description

1:1 adduct with acetic acid
STO-609 reduces tumorigenicity of liver cancer cells in vivo. TO-609 reduces the activation of AMP (adenosine monophosphate)-activated protein kinase (AMPK) by ionomycin in a dose dependant manner.

Application

STO609 has been used as a calcium/calmodulin-dependent protein kinase kinase (CAMKK) inhibitor in mouse MLL-AF9 acute myeloid leukemia (AML) cells.

Biochem/physiol Actions

Selective Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK) antagonist.
Selective Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK) antagonist. Inhibits CamKKa and CaMKKb with Ki = 80 and 15 ng/mL, respectively. Does not inhibit downstream CaM kinases (CaMKI and CaMKIV).

Features and Benefits

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML1697171256264158
STO-609-acetic acid ≥95% (HPLC), solid

Sigma-Aldrich

S1318

STO-609-acetic acid

OGG1 Inhibitor O8 ≥98% (HPLC)

Sigma-Aldrich

SML1697

OGG1 Inhibitor O8

AMPK Activator The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Sigma-Aldrich

171256

AMPK Activator

Caspase Modulator II, 1541B Caspase Modulator II, 1541B primarily used in Inhibition.

Sigma-Aldrich

264158

Caspase Modulator II, 1541B

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

solid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: 10 mg/mL

solubility

DMSO: 1.8 mg/mL

mp

>300 °C

mp

-

mp

-

mp

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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