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S0327

Sigma-Aldrich

Scutellarein

≥98% (HPLC)

Synonym(s):

4′,5,6,7-Tetrahydroxyflavone, 6-Hydroxyapigenin

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About This Item

Empirical Formula (Hill Notation):
C15H10O6
CAS Number:
529-53-3
Molecular Weight:
286.24
MDL number:
MFCD00017692
UNSPSC Code:
12352200
PubChem Substance ID:
329824421
NACRES:
NA.25

biological source

Erigeron breviscapus

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

DMSO: 1 mg/mL, clear, greenish-yellow

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1)C2=CC(=O)c3c(O)c(O)c(O)cc3O2

InChI

1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H

InChI key

JVXZRQGOGOXCEC-UHFFFAOYSA-N

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Biochem/physiol Actions

Flavonoid that is selectively cytotoxic toward cancer cells. Induces mitochondrial ROS, DNA damage, and metabolic suppression, preferentially in tumor cells. Scutellarein has been shown to have better absorption than scutellarin in Caco-2 monolayer cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiuhua Hao et al.
Journal of pharmaceutical and biomedical analysis, 38(2), 360-363 (2005-06-01)
A validated HPLC method was developed for the quantification of scutellarin in rat plasma using a liquid-liquid extraction and an ultraviolet detection. Chromatographic separation of scutellarin in plasma was performed on a C18 column, with a mobile phase of acetonitrile-water
Anna Berim et al.
Plant physiology, 160(2), 1052-1069 (2012-08-28)
Polymethoxylated flavonoids occur in a number of plant families, including the Lamiaceae. To date, the metabolic pathways giving rise to the diversity of these compounds have not been studied. Analysis of our expressed sequence tag database for four sweet basil
Xuesong Liu et al.
Journal of pharmaceutical sciences, 100(6), 2452-2459 (2011-01-20)
Antisolvent crystallization can be used as an alternative to cooling or evaporation for the separation and purification of solid product in the pharmaceutical industry. To improve the process understanding of antisolvent crystallization, the use of in-line tools is vital. In
Jian-feng Xing et al.
Acta pharmacologica Sinica, 32(5), 655-663 (2011-04-26)
To study the metabolic and pharmacokinetic profile of scutellarin, an active component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz, and to investigate the mechanisms underlying the low bioavailability of scutellarin though oral or intravenous administration in rats. HPLC method
Mi-Sun Yu et al.
Bioorganic & medicinal chemistry letters, 22(12), 4049-4054 (2012-05-15)
Severe acute respiratory syndrome (SARS) is an infectious disease with a strong potential for transmission upon close personal contact and is caused by the SARS-coronavirus (CoV). However, there are no natural or synthetic compounds currently available that can inhibit SARS-CoV.
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