P9564

Phleomycin

from Streptomyces verticillus, powder, DNA replication inhibitor

• Synonym(s): FT-0697305
• CAS Number: 11006-33-0
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00131846
• Form: powder

Properties

• Product Name: Phleomycin from Streptomyces verticillus, powder
• form: powder
• Quality Segment: 200
• shelf life: 2 yr
• color: blue
• antibiotic activity spectrum: fungi
• mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• InChI: 1S/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1
• InChI key: QRBLKGHRWFGINE-UGWAGOLRSA-N

Description

General description

Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.[1]

Application

Phleomycin from Streptomyces verticillus has been used as an antibiotic in the screening of transformants of Trypanosoma brucei[2]. It has also been used as an antibiotic in the maintenance of Escherichia coli.[3]

Biochem/physiol Actions

Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.[1]

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves