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N4037

Sigma-Aldrich

Anti-Netrin-G1a antibody produced in goat

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
MFCD07784853
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

indirect ELISA: 0.5-1 μg/mL using recombinant mouse netrin-G1a
western blot: 0.1-0.2 μg/mL using recombinant mouse netrin-G1a

UniProt accession no.

Q8R4G0

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Ntng1(80883)

General description

Netrin-G1a (NTNG1) is also known as laminet 1. It is expressed in axons and is a trans-synaptic adhesion protein. NTNG1 is part of the glycosylphosphatidylinositol-anchored subfamily of the UNC-6/netrin family.

Specificity

This antibody shows less than 2% cross-reactivity with rmNetrin-1, rhNetrin-2, and rhNetrin-4.

Immunogen

purified, insect cell line Sf 21-derived, recombinant mouse Netrin-G1a.

Biochem/physiol Actions

Netrin-G1a (NTNG1) stimulates the outgrowth of axons in the thalamo-cortical region of the brain and helps to excite the post-synaptic regions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hiroshi Matsukawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(47), 15779-15792 (2014-11-21)
Synaptic cell adhesion molecules are increasingly gaining attention for conferring specific properties to individual synapses. Netrin-G1 and netrin-G2 are trans-synaptic adhesion molecules that distribute on distinct axons, and their presence restricts the expression of their cognate receptors, NGL1 and NGL2
Kunio Yaguchi et al.
Molecular brain, 7, 19-19 (2014-03-20)
Higher brain function is supported by the precise temporal and spatial regulation of thousands of genes. The mechanisms that underlie transcriptional regulation in the brain, however, remain unclear. The Ntng1 and Ntng2 genes, encoding axonal membrane adhesion proteins netrin-G1 and
Elena Seiradake et al.
The EMBO journal, 30(21), 4479-4488 (2011-09-29)
Brain wiring depends on cells making highly localized and selective connections through surface protein-protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the structurally uncharacterized netrin family. We present a comprehensive crystallographic analysis comprising

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