N170

NS 1619

powder

• Synonym(s): 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
• Empirical Formula (Hill Notation): C₁₅H₈F₆N₂O₂
• CAS Number: 153587-01-0
• Molecular Weight: 362.23
• NACRES: NA.32
• PubChem Substance ID: 24277860
• UNSPSC Code: 12352200
• MDL number: MFCD00928190

Properties

• form: powder
• Quality Segment: 200
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL, ethanol: 26.6 mg/mL, 0.1 M NaOH: 5.2 mg/mL, DMSO: 5.3 mg/mL, H₂O: insoluble
• SMILES string: Oc1ccc(cc1N2C(=O)Nc3cc(ccc23)C(F)(F)F)C(F)(F)F
• InChI: 1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
• InChI key: YLFMCMWKHSDUCT-UHFFFAOYSA-N
• Gene Information: mouse ... Kcnma1(16531) ; rat ... Kcnma1(83731)

Description

Application

NS 1619 has been used as calcium-activated potassium channels (BK)-activator: to study its vaso-relaxing effects on the thoracic aortic rings from mice[1], to evaluate its effects on the sarco-/endoplasmic reticulum Ca²⁺-ATPase (SERCA) activity from skeletal muscles[2], to determine its effects on the expression of caveolin-1 protein in mice brain tumor microvascular endothelial cells[3]

Biochem/physiol Actions

NS 1619 is a selective large conductance Ca²⁺-activated K⁺-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.

NS-1619 can promote the formation of mitochondrial reactive oxygen species (ROS) in cardiac myocytes. It enhances the formation of ROS in cultured brain slices. NS-1619 has the ability to enhance HO-1 activity in wild-type (WT) animals.

Disclaimer

Photosensitive

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)