N1530

Nomifensine maleate salt

dopamine uptake inhibitor , powder

• Synonym(s): 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate salt
• Empirical Formula (Hill Notation): C₁₆H₁₈N₂ · C₄H₄O₄
• CAS Number: 32795-47-4
• Molecular Weight: 354.40
• NACRES: NA.77
• PubChem Substance ID: 24277920
• UNSPSC Code: 12352200
• EC Number: 251-223-7
• MDL number: MFCD00069320
• Form: powder

Properties

• Product Name: Nomifensine maleate salt,
• form: powder
• Quality Segment: 200
• SMILES string: [H]\C(=C(/[H])C(O)=O)C(O)=O.CN1CC(c2ccccc2)c3cccc(N)c3C1
• InChI: 1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: GEOCVSMCLVIOEV-BTJKTKAUSA-N
• Gene Information: human ... DBH(1621), SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

Description

Application

Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.

Biochem/physiol Actions

Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter,[1] at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves