K0515
Anti-Potassium Channel Kv12.1 (Elk1) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-KCNH8, Anti-Voltage gated K+ channel subfamily H member 8, Anti-ether-a-go-go like K+ channel 3
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
western blot: 1:200 using rat cortex lysates
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Kcnh8(246325)
General description
Kv12.1 channel is confined mainly to the central nervous system with some expression in peripheral organs such as testis, colon and lung. The physiological function of the Kv12.1 channel hasn′t been established, although a role in the modulation of overall excitability of neurons has been suggested.
The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8), also referred to as Elk1/Ets-1, belongs to the Ets family of transcription factors. The members of this subfamily are part of the ether-a-go-go (EAG) family of potassium channel pore-forming subunits. The rat elk mRNA is found to be expressed in brain. The rat elk subunits contain six hydrophobic membrane-spanning segments S1-S6, a P-domain, and a motif homologous to cyclic nucleotide-binding domains at the C-terminus.
Immunogen
peptide EDKKEDRAKGRSRAG(C) corresponding to amino acid residues 143-157 of rat KV12.1.
Biochem/physiol Actions
The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8) encodes a potassium channel pore-forming subunit that activates p21WAF1/Cip1 via cis-acting elements in p21WAF1/Cip1 and inhibits apoptosis of vascular smooth muscle cells. The potassium channel is found to mediate slowly activating sustained potassium currents.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.
Preparation Note
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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