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J4080

JTE-013

≥98% (HPLC), sphingosine 1-phosphate (S1P) receptor antagonist, powder

Synonym(s):

1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide

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5 mg
Please contact Customer Service for Availability
PLN 791.00
PLN 672.35
25 mg
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PLN 2,660.00

About This Item

Empirical Formula (Hill Notation):
C17H19N7OCl2
CAS Number:
383150-41-2
Molecular Weight:
408.29
UNSPSC Code:
12352211
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

PLN 672.35

List PricePLN 791.00Save 15%
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Product Name

JTE-013, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

Clc1nc(cc(c1)NC(=O)NNc2nc3[n](nc(c3c(c2)C(C)C)C)C)Cl

InChI

1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)

InChI key

RNSLRQNDXRSASX-UHFFFAOYSA-N

Application

JTE-013 has been used in in vitro blood−brain barrier (BBB) and blood−tumor barrier (BTB) assays.

Biochem/physiol Actions

JTE-013 is a selective sphingosine 1-phosphate (S1P) receptor antagonist.
JTE-013 is a selective sphingosine 1-phosphate (S1P) receptor antagonist. JTE-013 is highly selective for S1P2 (EDG-5). It inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. At concentrations up to 10 mM, JTE-013 displays 4.2% inhibition of S1P3 and does not antagonise S1P1.
JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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SML2822SML0766SML2810
JTE-013 ≥98% (HPLC)

Sigma-Aldrich

J4080

JTE-013

AZ12601011 ≥98% (HPLC)

Sigma-Aldrich

SML2822

AZ12601011

GSK343 ≥98% (HPLC)

Sigma-Aldrich

SML0766

GSK343

Prostetin Trifluoroacetic acid salt ≥98% (HPLC)

Sigma-Aldrich

SML2810

Prostetin Trifluoroacetic acid salt

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to off-white

color

white to light brown

color

, white to beige to brown

color

white to beige

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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